Structure–activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors
نویسندگان
چکیده
منابع مشابه
Inhibitors of protein synthesis in rat liver microsome fractions.
Rat liver microsome fractions contain two general kinds of inhibitors of amino acid incorporation in vitro. The first is derived from lysosomes contaminating the microsome fractions. Lysosomes may be removed from rough vesicles (ribosomes plus endoplasmic membranes) by a density centrifugation technique. Lysosomal inhibition of incorporation in vitro is much more prominent in normal than in reg...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Pyrrole detection by BeO nanotube: DFT studies
Electrical sensitivity of a beryllium oxide nanotube (BeONT) was examined toward (C4H5N) molecule by using density functional theory (DFT) calculations at the B3LYP/6-31(d) level, and it was found that the adsorption energy (Ead) of pyrrole on the pristine nanotubes is a bout -48.58kcal/mol. But when nanotubes has been doped with S and P atomes , the adsorptio...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
QSAR and Molecular Docking Studies of Oxadiazole-Ligated Pyrrole Derivatives as Enoyl-ACP (CoA) Reductase Inhibitors
A quantitative structure-activity relationship model was developed on a series of compounds containing oxadiazole-ligated pyrrole pharmacophore to identify key structural fragments required for anti-tubercular activity. Two-dimensional (2D) and three-dimensional (3D) QSAR studies were performed using multiple linear regression (MLR) analysis and k-nearest neighbour molecular field analysis (kNN...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2008
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2008.04.048